https://www.mrsantoslab.org/publications-index daily 0.75 2026-03-11 https://www.mrsantoslab.org/publications-index/2025/08/14/chd1-is-a-synthetic-lethal-vulnerability-in-myc-driven-breast-cancer monthly 0.5 2026-03-11 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/3dad4a78-846d-4ce0-a5f3-0971b686ab08/202508_BioRxiv_image.png Publications_Index - CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer - Make it stand out Model for the effect of CHD1 KD in MYC-driven breast cancer. By analysing two unbiased genome-wide screens, we identify and validate the chromatin remodeler CHD1 as a synthetic lethal vulnerability in a xenograft model of MYC-driven breast cancer. https://www.mrsantoslab.org/publications-index/2025/07/16/alpha-satellite-rna-marks-the-perinucleolar-compartment-and-represses-ribosomal-rna-expression-in-nave-human-embryonic-stem-cells monthly 0.5 2026-03-10 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/99c3c207-7661-4f88-9d9c-225ac5abbf50/202507_BioRxiv_image.png Publications_Index - Alpha satellite RNA marks the perinucleolar compartment and represses ribosomal RNA expression in naïve human embryonic stem cells - Make it stand out Model for the role of ALR RNA in naïve human ESCs https://www.mrsantoslab.org/publications-index/2025/09/08/nodalsmad2-signaling-sustains-developmental-pausing-by-repressing-pparg-mediated-lipid-metabolism monthly 0.5 2025-10-22 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/9f3f9b95-9913-4d4d-a7a7-90c48459d289/202509_BioRxiv_image.png Publications_Index - Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mrsantoslab.org/publications-index/2025/03/11/20-years-of-stemness-from-stem-cells-to-hypertranscription-and-back monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1741806873958-D1TVWWIG3PE2J24Q6U08/202503_Cell-Report_image.jpg Publications_Index - 20 years of stemness: From stem cells to hypertranscription and back - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mrsantoslab.org/publications-index/2024/12/20/line1-elements-at-distal-junctions-of-rdna-repeats-regulate-nucleolar-organization-in-human-embryonic-stem-cells monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/377dbe4a-dbaa-4c8d-a62f-b89245f32e77/2024_Dec_pub_image.png Publications_Index - LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mrsantoslab.org/publications-index/2024/9/25/line1-promotes-nuclear-compartmentalization-to-repress-the-8-cell-state-in-embryonic-stem-cells-1 monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1746803848818-6OR7IJOJ611T6CZIMTX0/202410_Dev-Cell_image.jpg Publications_Index - LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mrsantoslab.org/publications-index/2024/9/13/hypertranscription-the-invisible-hand-in-stem-cell-biology monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/177d5628-342e-4352-8013-9b02c5d5ec86/kim+et+al.jpg Publications_Index - Hypertranscription: the invisible hand in stem cell biology - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mrsantoslab.org/publications-index/2023/2/2/m6a-rna-methylation-orchestrates-transcriptional-dormancy-during-developmental-pausing monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/48f0edb9-bc45-43a3-8031-60bfaa7e02ff/Evelyn_Sep_2023_figure.png Publications_Index - m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mrsantoslab.org/publications-index/2023/1/12/absolute-scaling-of-single-cell-transcriptomes-identifies-pervasive-hypertranscription-in-adult-stem-and-progenitor-cells monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/7e308a01-5fce-46ed-9bf4-0d372dcdc70f/Kim+et+al+12072022+Graphical+Abstract.tif.jpg Publications_Index - Absolute scaling of single-cell transcriptomes identifies pervasive hypertranscription in adult stem and progenitor cells - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mrsantoslab.org/publications-index/2022/8/30/regulation-functions-and-transmission-of-bivalent-chromatin-during-mammalian-development monthly 0.5 2025-10-09 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/037d7cbe-aa19-4ef7-908c-e2eb96196cb8/FbFeLxZWIAAVYYt.jpeg Publications_Index - Regulation, functions and transmission of bivalent chromatin during mammalian development - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mrsantoslab.org/publications-index/2021/8/16/depletion-of-nuclear-line1-rna-in-mouse-escs-and-embryos monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1629166636411-NEDQ70T7V9BXCZF33RU1/1-s2.0-S2666166721004330-fx1_lrg.jpg Publications_Index - Depletion of nuclear LINE1 RNA in mouse ESCs and embryos - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.mrsantoslab.org/publications-index/2020/12/29/chd1-regulates-repair-of-promoter-proximal-dna-breaks-to-sustain-hypertranscription-in-embryonic-stem-cells monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/2afc59fc-ce61-4823-91eb-39ba1c2ba334/picture2.png Publications_Index - Chd1 regulates repair of promoter-proximal DNA breaks to sustain hypertranscription in embryonic stem cells https://www.mrsantoslab.org/publications-index/2020/6/29/the-deubiquitinase-usp9x-regulates-prc2-mediated-chromatin-reprogramming-during-mouse-development monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1593455054271-2XIBJQLGCYAGWWUD9F1R/tm.jpg Publications_Index - The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development https://www.mrsantoslab.org/publications-index/2021/2/5/homotypic-clustering-of-l1-and-b1alu-repeats-compartmentalizes-the-3d-genome monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/cf9095ce-75bc-4b6e-9e1b-c95ab8e5cbf1/Picture1.png Publications_Index - Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome https://www.mrsantoslab.org/publications-index/2021/1/20/colorectal-cancer-cells-enter-a-diapause-like-dtp-state-to-survive-chemotherapy monthly 0.5 2025-08-14 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https://www.mrsantoslab.org/publications-index/2020/2/19/what-doesnt-kill-you-makes-you-stronger-transposons-as-dual-players-in-chromatin-regulation-and-genomic-variation monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1582124037407-Y0FBSFLX8NZUUIVBIVNU/pubmed.jpeg Publications_Index - What Doesn’t Kill You Makes You Stronger: Transposons as Dual Players in Chromatin Regulation and Genomic Variation https://www.mrsantoslab.org/publications-index/2019/9/5/maternal-vitamin-c-regulates-reprogramming-of-dna-methylation-and-germline-development monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1567715838144-H2EQ9IIB3NAXN4PYMY1S/DiTroia+Nature+2019compressed.jpg Publications_Index - Maternal vitamin C regulates reprogramming of DNA methylation and germline development https://www.mrsantoslab.org/publications-index/2018/6/19/a-line1-nucleolin-partnership-regulates-early-development-and-esc-identity monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1530108417558-D04YCD7M9XIJ7GOT7FTB/fx1.jpg Publications_Index - A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity. https://www.mrsantoslab.org/publications-index/the-transcriptionally-permissive-chromatin-state-of-embryonic-stem-cells-is-acutely-tuned-to-translational-output monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1528592103853-AE31CCWPKVAAI2OF5EQG/image-asset.jpeg Publications_Index - The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output. https://www.mrsantoslab.org/publications-index/tet2-rescues-age-related-regenerative-decline-and-enhances-cognitive-function-in-the-adult-mouse-brain monthly 0.5 2025-08-14 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1528592884814-L359SF2GLPH307XHJA6Z/gr1.jpg Publications_Index - Tet2 Rescues 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https://www.mrsantoslab.org/publications-index/2016/12/1/inhibition-of-mtor-induces-a-paused-pluripotent-state monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/yap-induces-human-naive-pluripotency monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/2015/10/1/unwind-and-transcribe-chromatin-reprogramming-in-the-early-mammalian-embryo monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/2015/4/7/emergence-of-hematopoietic-stem-and-progenitor-cells-involves-a-chd1-dependent-increase-in-total-nascent-transcription monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/hitselect-a-comprehensive-tool-for-high-complexity-pooled-screen-analysis monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/2015/1/1/chd1-is-essential-for-the-high-transcriptional-output-and-rapid-growth-of-the-mouse-epiblast monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/2014/11/20/a-comparative-encyclopedia-of-dna-elements-in-the-mouse-genome monthly 0.5 2025-11-07 https://www.mrsantoslab.org/publications-index/2014/8/11/hira-mediated-h33-incorporation-is-required-for-dna-replication-and-ribosomal-rna-transcription-in-the-mouse-zygote monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/2014/7/17/systematic-identification-of-barriers-to-human-ipsc-generation monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/2013/12/15/somatic-cells-regulate-maternal-mrna-translation-and-developmental-competence-of-mouse-oocytes monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/2013/9/1/histone-variant-h33-maintains-a-decondensed-chromatin-state-essential-for-mouse-preimplantation-development monthly 0.5 2025-08-14 https://www.mrsantoslab.org/publications-index/2018/6/10/vitamin-c-induces-tet-dependent-dna-demethylation-and-a-blastocyst-like-state-in-es-cells monthly 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BBQ at the Golden Gate Park - 2014 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/be014ab8-5d7d-4b27-980e-bfd3759bc7a9/06_2013_ski-trip.jpg Gallery - Ski Trip - 2013 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/64c1e157-62b5-4ee2-b536-a48894a22116/05_2012_paper-party.jpg Gallery - Paper Party - 2012 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/a2de2f5e-9bf9-42b7-929b-e1e6adf765da/03_2011_ski-trip.jpg Gallery - Ski Trip - 2011 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/099a9669-4449-4c2d-b529-e5c475307b11/01_2005_1st-lab-at-beach.jpg Gallery - First lab at the beach - 2005 https://www.mrsantoslab.org/research daily 0.75 2026-03-13 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/e4360402-1871-49b0-bbf6-0350ccae0d8e/01_StCHyTx_sqr.jpg https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/c01872c5-e442-4561-a9cb-df5b637757ba/02_Pausing.jpg https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/542f992e-234e-45e7-bcd9-311f02ffcd39/03_Transposons.jpeg https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/cd065cd0-93e0-492b-9e93-97ffbfc83c89/04_Env.png https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/e4360402-1871-49b0-bbf6-0350ccae0d8e/01_StCHyTx_sqr.jpg Research Simon McGrath, “Who Left The Tap On” https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/c01872c5-e442-4561-a9cb-df5b637757ba/02_Pausing.jpg Research Salvador Dalí, “The Disintegration of the Persistence of Memory” https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/542f992e-234e-45e7-bcd9-311f02ffcd39/03_Transposons.jpeg Research Vera Molnár, “(Des)Ordes” https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/cd065cd0-93e0-492b-9e93-97ffbfc83c89/04_Env.png Research Katsushika Hokusai, “The Great Wave off Kanagawa”, adapted by Evelyne Collignon https://www.mrsantoslab.org/logo daily 0.75 2025-07-08 https://images.squarespace-cdn.com/content/v1/5b1c0762372b969037dc2af5/1529615745062-Z7WP9DIGRWNKBCIIIKO7/conrad_merged.jpg https://www.mrsantoslab.org/pub-new daily 0.75 2025-11-07