Publications From The Santos Lab
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming.
Authors: Qin H, Blaschke K, Wei G, Ohi Y, Blouin L, Qi Z, Yu J, Yeh RF, Hebrok M, Ramalho-Santos M.
Reference: Hum Mol Genet. 2012 May 1;21(9):2054-67. doi: 10.1093/hmg/dds023. Epub 2012 Jan 27.
PMID: 22286172
Polycomb-like 3 promotes polycomb repressive complex 2 binding to CpG islands and embryonic stem cell self-renewal.
Authors: Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M, Krogan N, Ren B, Song JS, Reiter JF.
Reference: PLoS Genet. 2012;8(3):e1002576. doi: 10.1371/journal.pgen.1002576. Epub 2012 Mar 15.
PMID: 22438827
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.
Authors: Ohi Y, Qin H, Hong C, Blouin L, Polo JM, Guo T, Qi Z, Downey SL, Manos PD, Rossi DJ, Yu J, Hebrok M, Hochedlinger K, Costello JF, Song JS, Ramalho-Santos M.
Reference: Nat Cell Biol. 2011 May;13(5):541-9. doi: 10.1038/ncb2239. Epub 2011 Apr 17.
PMID: 21499256
Open chromatin in pluripotency and reprogramming.
Authors: Gaspar-Maia A, Alajem A, Meshorer E, Ramalho-Santos M.
Reference: Nat Rev Mol Cell Biol. 2011 Jan;12(1):36-47. doi: 10.1038/nrm3036. Review. Erratum in: Nat Rev Mol Cell Biol. 2011 Apr;12(4):273.
PMID: 21179060
Parallel gateways to pluripotency: open chromatin in stem cells and development.
Authors: Koh FM, Sachs M, Guzman-Ayala M, Ramalho-Santos M.
Reference: Curr Opin Genet Dev. 2010 Oct;20(5):492-9. doi: 10.1016/j.gde.2010.06.002. Epub 2010 Jul 2. Review.
PMID: 20598875
iPS cells: insights into basic biology.
Authors: Ramalho-Santos M.
Reference: Cell. 2009 Aug 21;138(4):616-8. doi: 10.1016/j.cell.2009.08.012.
PMID: 19703387
Chd1 regulates open chromatin and pluripotency of embryonic stem cells.
Authors: Gaspar-Maia A, Alajem A, Polesso F, Sridharan R, Mason MJ, Heidersbach A, Ramalho-Santos J, McManus MT, Plath K, Meshorer E, Ramalho-Santos M.
Reference: Nature. 2009 Aug 13;460(7257):863-8. doi: 10.1038/nature08212. Epub 2009 Jul 8.
PMID: 19587682
CompMoby: comparative MobyDick for detection of cis-regulatory motifs.
Authors: Chaivorapol C, Melton C, Wei G, Yeh RF, Ramalho-Santos M, Blelloch R, Li H.
Reference: BMC Bioinformatics. 2008 Oct 27;9:455. doi: 10.1186/1471-2105-9-455.
PMID: 18950538
The pluripotent transcriptome.
Authros: Grskovic M, Ramalho-Santos M.
Reference: StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-. 2008 Oct 10.
PMID: 20614622
High-efficiency stem cell fusion-mediated assay reveals Sall4 as an enhancer of reprogramming.
Authors: Wong CC, Gaspar-Maia A, Ramalho-Santos M, Reijo Pera RA.
Reference: PLoS One. 2008 Apr 16;3(4):e1955. doi: 10.1371/journal.pone.0001955.
PMID: 18414659
Generation of induced pluripotent stem cells in the absence of drug selection.
Authors: Blelloch R, Venere M, Yen J, Ramalho-Santos M.
Reference: Cell Stem Cell. 2007 Sep 13;1(3):245-7. doi: 10.1016/j.stem.2007.08.008. Epub 2007 Sep 6. No abstract available.
PMID: 18371358
Systematic identification of cis-regulatory sequences active in mouse and human embryonic stem cells.
Authors: Grskovic M, Chaivorapol C, Gaspar-Maia A, Li H, Ramalho-Santos M.
Reference: PLoS Genet. 2007 Aug;3(8):e145.
PMID: 17784790
On the origin of the term "stem cell".
Authors: Ramalho-Santos M, Willenbring H.
Reference: Cell Stem Cell. 2007 Jun 7;1(1):35-8. doi: 10.1016/j.stem.2007.05.013.
PMID: 18371332
RNA interference in embryonic stem cells and the prospects for future therapies.
Authors: Heidersbach A, Gaspar-Maia A, McManus MT, Ramalho-Santos M.
Reference: Gene Ther. 2006 Mar;13(6):478-86. Review.
PMID: 16520820
Stem cells as probabilistic self-producing entities.
Authors: Ramalho-Santos M.
Reference: Bioessays. 2004 Sep;26(9):1013-6.
PMID: 15351971
"Stemness": transcriptional profiling of embryonic and adult stem cells.
Authors: Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA.
Reference: Science. 2002 Oct 18;298(5593):597-600. Epub 2002 Sep 12.
PMID: 12228720
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node.
Authors: Zhang XM, Ramalho-Santos M, McMahon AP.
Reference: Cell. 2001 Jul 27;106(2):781-92.
PMID: 11517919
Hedgehog signals regulate multiple aspects of gastrointestinal development.
Authors: Ramalho-Santos M, Melton DA, McMahon AP.
Reference: Development. 2000 Jun;127(12):2763-72.
PMID: 10821773
Will cell alliance breed bureaucracy and leave contributors out?
Authors: Haggarty SJ, Ramalho-Santos M.
Reference: Nature. 2000 Feb 10;403(6770):591. No abstract available.
PMID: 10688171
Cloning and characterization of cDNA encoding cardosin A, an RGD-containing plant aspartic proteinase.
Authors: Faro C, Ramalho-Santos M, Vieira M, Mendes A, Simões I, Andrade R, Veríssimo P, Lin X, Tang J, Pires E.
Reference: J Biol Chem. 1999 Oct 1;274(40):28724-9.
PMID: 10497243