Discussed @mrsantos.bsky.social lit review: Identification of genes supporting cold resistance of mammalian cells: lessons from a hibernator. www.nature.com/articles/s41...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) May 6, 2025 at 9:54 AM

Also noted: The first two blastomeres contribute unequally to the human embryo. www.cell.com/cell/fulltex...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) May 6, 2025 at 9:54 AM

Discussed @mrsantos.bsky.social lit review: Genome-coverage single-cell histone modifications for embryo lineage tracing. www.nature.com/articles/s41...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) April 30, 2025 at 9:34 AM

Also noted: The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways. www.cell.com/cell/fulltex...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) April 30, 2025 at 9:34 AM

Discussed @mrsantos.bsky.social lit review: How epigenetic inheritance fails to explain the Black-White health gap. www.sciencedirect.com/science/arti...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) April 23, 2025 at 10:03 AM

Also noted: Interchromosomal contacts between regulatory regions trigger stable transgenerational epigenetic inheritance in Drosophila. www.cell.com/molecular-ce...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) April 23, 2025 at 10:03 AM

Discussed @mrsantos.bsky.social lit review: RNA polymerase II at histone genes predicts outcome in human cancer. www.science.org/doi/10.1126/...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) April 2, 2025 at 3:03 PM

Also noted: Oxytocin induces embryonic diapause. www.science.org/doi/10.1126/...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) April 2, 2025 at 3:03 PM

Thank you @isscr.org Stem Cell Reports for selecting our work for the March cover! Caption: (1/3) In this issue, Kim and Ramalho-Santos provide a perspective on the history of stem cell transcriptomics. They show that a stemness signature from the early 2000’s foreshadowed hypertranscription.

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) Mar 13, 2025 at 5:58 PM

(2/3) Hypertranscription is the global elevation of the transcriptome that stem and progenitor cells engage in at times of growth and regeneration. The cover image features a background from a microarray experiment of 2002, with each square reporting on the expression of a gene.

— Miguel Ramalho-Santos (@mrsantos.bsky.social) Mar 13, 2025 at 5:58 PM

(3/3) Overlayed is a representation of single-cell RNA sequencing data from 2024, where each dot highlights the levels of the stemness signature in hematopoietic cells (hypertranscribing stem and progenitor cells are in green/yellow).

— Miguel Ramalho-Santos (@mrsantos.bsky.social) Mar 13, 2025 at 5:58 PM

🔃 Reposted by Miguel Ramalho-Santos:

Read the recent review by @mrsantos.bsky.social that marks two decades of stem cell breakthroughs 🔬 🙌 🎉 Discover how a serendipitous discovery of a stem cell gene signature has led to understanding hypertranscription, with implications for health and disease. www.cell.com/stem-cell-re...

— Research at Sinai Health (@sinaihealth.bsky.social) February 13, 2025 at 11:14 AM

Out now at Stem Cell Reports @isscr.org: a Perspective on the history of stem cell transcriptomics. We show that a stemness signature from the early 2000’s (Miguel's PhD work) foreshadowed stem cell hypertranscription. Thanks @pairedbox.bsky.social for this adventure! www.cell.com/stem-cell-re...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) Feb 7, 2025 at 2:50 PM

Want a break for the news cycle and are curious to learn more about stem cell hypertranscription? (why wouldn't you?): Read about it in this Perspective and more details in this Review: www.cell.com/trends/genet...

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) February 7, 2025 at 2:50 PM

🗞️Breaking News: our team was just awarded a new, 5-year CIHR Project Grant for our studies of the regulation of hypertranscription! We are very grateful to the Canadian Institutes of Health Research for their continued support of our research in developmental epigenetics. @sinaihealth.bsky.social

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— Miguel Ramalho-Santos (@mrsantos.bsky.social) January 29, 2025 at 2:33 PM

We found that copies of the LINE1 transposon are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together two facets of Barbara McClintock’s pioneering research: nucleolar organizer regions and transposable elements. www.genesdev.org/cgi/doi/10.1...

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— Miguel Ramalho-Santos (@mrsantoslab.bsky.social) January 2, 2025 at 3:36 PM

This study follows our earlier 2024 publication showing that RNA expressed from the LINE1 transposon prevents human embryonic cells from going back in developmental time. www.sciencedirect.com/science/arti...

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— Miguel Ramalho-Santos (@mrsantoslab.bsky.social) January 2, 2025 at 3:36 PM