Santos Lab 7/16/25 Santos Lab 7/16/25

Alpha satellite RNA marks the perinucleolar compartment and represses ribosomal RNA expression in naïve human embryonic stem cells

Authors: Mittal K, Ataei L, Ramalho-Santos M.

Reference: bioRxiv, 2025.07.11.664446; doi: 10.1101/2025.07.11.664446

Santos Lab 12/20/24 Santos Lab 12/20/24

LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells

Authors: Ataei L, Zhang J, Monis S, Giemza K, Mittal K, Yang J, Shimomura M, McStay B, Wilson MD, Ramalho-Santos M.
Reference: Genes Dev, 2025 Feb 3;39(3-4):280-298. doi: 10.1101/gad.351979.124
PMID: 39797762

Santos Lab 10/15/24 Santos Lab 10/15/24

LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs

Authors: Zhang J, Ataei L, Mittal K, Wu L, Caldwell L, Huynh L, Sarajideen S, Tse K, Simon MM, Mazid A, Cook DP, Trcka D, Kwan T, Hoffman MM, Wrana JL, Esteban MA, Ramalho-Santos M.

Reference: Developmental Cell, 2024. https://doi.org/10.1016/j.devcel.2024.09.024

Santos Lab 9/17/21 Santos Lab 9/17/21

Depletion of nuclear LINE1 RNA in mouse ESCs and embryos

Authors: Percharde M, Lin CJ, Ramalho-Santos M.

Reference: STAR Protoc, 2021 Aug 9;2(3):100726. doi: 10.1016/j.xpro.2021.100726

PMID: 34409306

Santos Lab 2/5/21 Santos Lab 2/5/21

Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome

Authors: Lu JY, Chang L, Li T, Wang T, Yin Y, Zhan G, Han X, Zhang K, Tao Y, Percharde M, Wang L, Peng Q, Yan P, Zhang H, Bi X, Shao W, Hong Y, Wu Z, Ma R, Wang P, Li W, Zhang J, Chang Z, Hou Y, Zhu B, Santos MR, Li P, Xie W, Na J, Sun Y, Shen X.

Reference : Cell Research. 2021 Jan 29, 10.1038/s41422-020-00466-6

PMID: 33514913

Santos Lab 3/10/20 Santos Lab 3/10/20

Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation

Authors: Lu JY, Shao W, Chang L, Yin Y, Li T, Zhang H, Hong Y, Percharde M, Guo L, Wu Z, Liu L, Liu W, Yan P, Ramalho-Santos M, Sun Y, Shen X.

Reference: Cell Rep. 2020 Mar 10; 30 (10) :3296-3311
PMID: 32160538

Santos Lab 2/19/20 Santos Lab 2/19/20

What Doesn’t Kill You Makes You Stronger: Transposons as Dual Players in Chromatin Regulation and Genomic Variation

Authors: Percharde M, Sultana T, Ramalho-Santos M.
Reference: Bioessays. 2020 Feb 13. https://onlinelibrary.wiley.com/doi/full/10.1002/bies.201900232
PMID: 32053231

Santos Lab 6/19/18 Santos Lab 6/19/18

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity.

Authors: Percharde M, Lin CJ, Yin Y, Guan J, Peixoto GA, Bulut-Karslioglu A, Biechele S, Huang B, Shen X, Ramalho-Santos M.
Reference: Cell. 2018 Jun 19. pii: S0092-8674(18)30655-X. doi: 10.1016/j.cell.2018.05.043.
PMID: 29937225

Publications From The Santos Lab