Publications From The Santos Lab
The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output.
Authors: Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, Covarrubias S, Percharde M, Ku G, Diaz A, McManus MT, Burlingame AL, Ramalho-Santos M.
Reference: Cell Stem Cell. 2018 Mar 1;22(3):369-383.e8. doi: 10.1016/j.stem.2018.02.004.
PMID: 29499153
Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.
Authors: Gontier G, Iyer M, Shea JM, Bieri G, Wheatley EG, Ramalho-Santos M, Villeda SA.
Reference: Cell Rep. 2018 Feb 20;22(8):1974-1981. doi: 10.1016/j.celrep.2018.02.001.
PMID: 29466726
Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b.
Authors: Ebata KT, Mesh K, Liu S, Bilenky M, Fekete A, Acker MG, Hirst M, Garcia BA, Ramalho-Santos M.
Reference: Epigenetics Chromatin. 2017 Jul 12;10:36. doi: 10.1186/s13072-017-0143-3. eCollection 2017.
PMID: 28706564
CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair
Authors: Shenoy TR, Boysen G, Wang MY, Xu QZ, Guo W, Koh FM, Wang C, Zhang LZ, Wang Y, Gil V, Aziz S, Christova R, Rodrigues DN, Crespo M, Rescigno P, Tunariu N, Riisnaes R, Zafeiriou Z, Flohr P, Yuan W, Knight E, Swain A, Ramalho-Santos M, Xu DY, de Bono J, Wu H.
Reference: Ann Oncol. 2017 Jul 1;28(7):1495-1507. doi: 10.1093/annonc/mdx165.
PMID: 28383660
Global Hypertranscription in the Mouse Embryonic Germline
Authors: Percharde M, Wong P, Ramalho-Santos M.
Reference: Cell Rep. 2017 Jun 6;19(10):1987-1996. doi: 10.1016/j.celrep.2017.05.036.
PMID: 28591571
Hypertranscription in Development, Stem Cells, and Regeneration.
Authors: Percharde M, Bulut-Karslioglu A, Ramalho-Santos M.
Reference: Dev Cell. 2017 Jan 9;40(1):9-21. doi: 10.1016/j.devcel.2016.11.010. Epub 2016 Dec 15. Review.
PMID: 27989554
Inhibition of mTOR induces a paused pluripotent state.
Authors: Bulut-Karslioglu A, Biechele S, Jin H, Macrae TA, Hejna M, Gertsenstein M, Song JS, Ramalho-Santos M.
Reference: Nature. 2016 Dec 1;540(7631):119-123. doi: 10.1038/nature20578. Epub 2016 Nov 23.
PMID: 27880763
YAP Induces Human Naive Pluripotency.
Authors: Qin H, Hejna M, Liu Y, Percharde M, Wossidlo M, Blouin L, Durruthy-Durruthy J, Wong P, Qi Z, Yu J, Qi LS, Sebastiano V, Song JS, Ramalho-Santos M.
Reference: Cell Rep. 2016 Mar 15;14(10):2301-12. doi: 10.1016/j.celrep.2016.02.036. Epub 2016 Mar 3.
PMID: 26947063
Unwind and transcribe: chromatin reprogramming in the early mammalian embryo.
Authors: Biechele S, Lin CJ, Rinaudo PF, Ramalho-Santos M.
Reference: Curr Opin Genet Dev. 2015 Oct;34:17-23. doi: 10.1016/j.gde.2015.06.003. Epub 2015 Jul 13. Review.
PMID: 26183187
Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription.
Authors: Koh FM, Lizama CO, Wong P, Hawkins JS, Zovein AC, Ramalho-Santos M.
Reference: Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1734-43. doi: 10.1073/pnas.1424850112. Epub 2015 Mar 23.
PMID: 25831528
HiTSelect: a comprehensive tool for high-complexity-pooled screen analysis.
Authors: Diaz AA, Qin H, Ramalho-Santos M, Song JS.
Reference: Nucleic Acids Res. 2015 Feb 18;43(3):e16. doi: 10.1093/nar/gku1197. Epub 2014 Nov 26.
PMID: 25428347
Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast.
Authors: Guzman-Ayala M, Sachs M, Koh FM, Onodera C, Bulut-Karslioglu A, Lin CJ, Wong P, Nitta R, Song JS, Ramalho-Santos M.
Reference: Development. 2015 Jan 1;142(1):118-27. doi: 10.1242/dev.114843. Epub 2014 Dec 5.
PMID: 25480920
A comparative encyclopedia of DNA elements in the mouse genome.
Authors: Yue F, Cheng Y, Breschi A, et al.
Reference: Nature. 2014 Nov 20;515(7527):355-64. doi: 10.1038/nature13992.
PMID: 25409824
Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote.
Authors: Lin CJ, Koh FM, Wong P, Conti M, Ramalho-Santos M.
Reference: Dev Cell. 2014 Aug 11;30(3):268-79. doi: 10.1016/j.devcel.2014.06.022. Epub 2014 Jul 31.
PMID: 25087892
Systematic identification of barriers to human iPSC generation.
Authors: Qin H, Diaz A, Blouin L, Lebbink RJ, Patena W, Tanbun P, LeProust EM, McManus MT, Song JS, Ramalho-Santos M.
Reference: Cell. 2014 Jul 17;158(2):449-461. doi: 10.1016/j.cell.2014.05.040.
PMID: 25036638
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes.
Authors: Chen J, Torcia S, Xie F, Lin CJ, Cakmak H, Franciosi F, Horner K, Onodera C, Song JS, Cedars MI, Ramalho-Santos M, Conti M.
Reference: Nat Cell Biol. 2013 Dec;15(12):1415-23. doi: 10.1038/ncb2873. Epub 2013 Nov 24.
PMID: 24270888
Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development.
Authors: Lin CJ, Conti M, Ramalho-Santos M.
Reference: Development. 2013 Sep;140(17):3624-34. doi: 10.1242/dev.095513. Epub 2013 Jul 31.
PMID: 23903189
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.
Authors: Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M.
Reference: Nature. 2013 Aug 8;500(7461):222-6. doi: 10.1038/nature12362. Epub 2013 Jun 30.
PMID: 23812591
Bivalent chromatin marks developmental regulatory genes in the mouse embryonic germline in vivo.
Authors: Sachs M, Onodera C, Blaschke K, Ebata KT, Song JS, Ramalho-Santos M.
Reference: Cell Rep. 2013 Jun 27;3(6):1777-84. doi: 10.1016/j.celrep.2013.04.032. Epub 2013 May 30.
PMID: 23727241
Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state.
Authors: Sakaki-Yumoto M, Liu J, Ramalho-Santos M, Yoshida N, Derynck R.
Reference: J Biol Chem. 2013 Jun 21;288(25):18546-60. doi: 10.1074/jbc.M112.446591. Epub 2013 May 6.
PMID: 23649632